Najimy was natural around San Diego, California and is of Lebanese descent. Her film career began in the early 1990's by having the total of off-quirky bit part, however her number one major role was in the 1992 comedy Sister Act, in the role of Sister Mary Patrick. She reprised this role in the 1993 in Sister Act 2. She too starred inside Hocus Pocus with Bette Midler and Sarah Jessica Parker as the Sanderson sisters.

From either film, Najimy expanded into televisiin roles, including the revenant role on Chicago Hope. Najimy was part of the cast of ''Veronica's Closet from 1997 to 2000. She besides co-wrote (by having actress Mo Gaffney) and asterisked in the theatrical production A Kathy & Mo Indicate. Beginning within 1997, she provided the voice of Peggy Hill on the alive series King of the Hill''.

Najimy married Dan Finnerty in August 1995; her first girl was innate inside 1996. Najimy is too noted as an militant for gay rights, as well as a women's rightist & person rights militant & is openly bisexual. She publicly admitted that she got got an abortion. She is besides the vegetarian. She appeared as the contestant in a celebrity version of "The Weakest Link" where she attempted to win money for Afghani women. Around 2004 she was chosen by Ms. Magazine as Woman of the Year.